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. Author manuscript; available in PMC: 2010 Jul 22.
Published in final edited form as: Med Innov Bus. 2009 Apr 1;1(1):52–66. doi: 10.1097/01.MNB.0000357626.97020.e5

Table 1.

Summary of University of Colorado Proof of Concept funding programs, scope, aims and funding objectives.

Program Form Scope and Criteria Example endpoints
Proof of Concept grant (POCg) $10,000 to $25,000
Grant to faculty laboratory		 IP expansion, concept validation,
enable NIH and Foundation grants
for translational projects		 Study proof-of concept molecule
in vitro; format an assay for
clincially relevant biomarker; build
device prototypes
Proof of Concept investment (POCi) Up to $100,000
Loan (uncollateralized) to CU
startup company, with IP from
CU, convertible to stock		 Clinical or commercial proof of
principle; "investable endpoints"		 In vivo efficacy of proprietary
therapeutics; prospective
validation of a diagnostic; in vivo
evaluation or performace testing
of a device
Proof of Concept State Bill POCsb) Up to $200,000
Grant to faculty laboratory		 Broader aims from POCg to
commercial; should augment
venture quality projects		 Preclincial or clinical evaluation;
pre-regulatory work; projects
defined as investment-contingent
by venture investors