Figure 2.
The p3 (Aβ17−42) monomer extracted from the NMR pentamer(34) shown by the peptide backbone in a ribbon representation (left). Building an annular channel structure with the CNpNC topology embedded in the lipid bilayers using the NMR-based p3 monomer (right). In the peptide, hydrophobic residues are shown in white, two polar residues (Ser26 and Asn27) and five Gly residues (at locations 25, 29, 33, 37, and 38) are shown in green, a positively charged residue (Lys28) is shown in blue, and two negatively charged residues (Glu22 and Asp23) are shown in red. Key residues (Phe19, Glu22, Asp23, Lys28, and Met35) are marked.