Figure 4.
Averaged pore structures calculated by the HOLE program(48) embedded in the averaged channel conformations during the simulations for the 12-, 16-, 20-, 24-, and 36-mer p3 (Aβ17−42) channels. The 12-, 16-, 20-, and 36-mer structures were obtained from the simulations in the zwitterionic DOPC bilayer. The 24-mer structure was obtained from the anionic bilayer containing POPC and POPG with a molar ratio of 4:1. In the angle views of the pore structure (upper row), whole channel structures are shown with the ribbon representation with the same color representations described in Figure 2. In the lateral views of the pore structure (lower row), cross-sectioned channels are given in the surface representation with the same color representations used in Figure 2. For the pore structures in the surface representation, the degree of the pore diameter is indicated by the color codes in the order of red < green < blue, but the scale of these colors is relative to each channel.