Studies of stroke, hypertension, and carotid atherosclerosis from 2000 to 2010
| Study | Year | Cases/sample or controls | Age range, y | Ethnic group | Design | APOE | Outcome | Risk estimate (95% CI) |
|---|---|---|---|---|---|---|---|---|
| McCarron et al. [44] | 1999 | 9 studies | NA | Japanese, Canadian, European | Meta-analysis of 9 case-control studies | Any e4+ | Ischemic CVD | 1.68 (1.36–2.09) |
| Slooter et al. [20] | 2004 | 149/6852 | 55 + | Dutch | Cohort | e3/e4 e4/e4 | Ischemic stroke | 0.9 (0.6–1.3) 0.6 (0.1–2.5) |
| van Vliet et al. [34] | 2007 | 99/561 | 85+ | Dutch | Cohort | e3/e4+ | Stroke | 3.01 (1.34–6.74) |
| Wang et al. [45•] | 2009 | 396/396 | 57 (mean) | Han Chinese | Case control | Any e4+ | Stroke | 1.50 (1.13–1.91) |
| Sturgeon et al. [46] | 2007 | 180/5054 | 45–64 | US white men | Cohort | Any e4+ | Ischemic stroke | 0.98 (0.70–1.38) |
| Sturgeon et al. [46] | 2007 | 97/1499 | 45–64 | US black men | Cohort | Any e4+ | Ischemic stroke | 0.77 (0.49–1.24) |
| Banerjee et al. [47] | 2007 | 6107 | 50–70 | Asian | Meta-analysis | Any e4+ | Stroke | 1.47 (1.00, 2.15) |
| Lahoz et al. [42] | 2001 | 242/1668 | 11–65 | US white men | Cohort | Any e4+ | CVD | 1.46 (0.99–2.15) |
| Niu et al. [10] | 2009 | 1812/1762 | 40+ | Asian | Meta-analysis of 6 case-control studies | Any e4+ | Hypertension | 1.97 (1.11–3.52) |
| Volcik et al. [19] | 2006 | 15,792 | 45–64 | US white and black | Cohort | Any e4+ | Carotid IMT (mean [SE])a | e4: 0.74 (0.003) |
| Debette et al. [48] | 2006 | 5856 | 65+ | European | Cohort | e4/e4 vs. e33 | Carotid plaque | 2.12 (1.27–3.53) |
| Beilby et al. [49] | 2003 | 1109 | 27–77 | Australian white men | Cross-sectional | e4/e4 e3/e4 | Carotid plaque | 2.85 (0.49–16.6) 1.79 (1.01–3.17) |
APOE apolipoprotein E; CVD cardiovascular disease; IMT intimal media thickness
a P < 0.05 versus e33