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. 2010 May 28;19(16):3105–3113. doi: 10.1093/hmg/ddq211

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Figure 2. — Avc1 caused AVSDs and polydactyly and mapped to chromosome 5. (A and B) Morphology of control litter mate (A) and avc1 (B) mutant newborn mouse hearts. Avc1 hearts demonstrated highly penetrant AVSDs (red asterisk). (C and D) Morphology of control litter mate (C) and avc1 mutant mouse (D) upper limbs. avc1 upper limbs demonstrated penetrant preaxial polydactyly (red arrowhead). (E) Avc1 maps to proximal chromosome 5. Recombinant chromosomes in affected animals refined the interval containing avc1 to 3.6 Mb between D5Mit229 and D5Mit420.