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Avc3 caused AVSDs and mapped to chromosome 9. (A and B) Morphology of control litter mate (A) and avc3 mutant E17.5 mouse hearts. Avc3 hearts demonstrated highly penetrant AVSDs (B, red asterisk). (C) Avc3 maps to proximal chromosome 9. Recombinant chromosomes in affected animals refined the interval containing avc3 to 6.5 Mb between D9Mit106 and D9Mit302.
