Table 1.

Primary screen of 2880 compounds

Library	% reduction	Compounds n (%)
		Promoter screen	Protein screen
Prestwick	<50	772	856
	50–75	37 (4.2%)	20 (2.3%)
	75–90	30 (3.4%)	4 (0.5%)
	90–100	41 (4.6%)	0
Spectrum	<50	1752	1964
	50–75	105 (5.3%)	33 (1.7%)
	75–90	52 (2.6%)	3 (0.1%)
	90–100	91 (4.5%)	0

Summary of results from primary screen of 2880 compounds derived from the Prestwick and Spectrum libraries, in both luciferase (GFAP promoter) and ELISA (GFAP protein) assays. Cells were exposed to each compound at 10 µm for 48 h, using one well per compound. No corrections were made for potential effects on cell survival.