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. Author manuscript; available in PMC: 2011 Jul 8.
Published in final edited form as: J Med Chem. 2010 Jul 8;53(13):4813–4829. doi: 10.1021/jm100086u

Scheme 7.

Scheme 7

Structure of the synthetic peptidoglycan82,273 used in the determination of the crystal structure of a Michaelis complex-like structure with E. coli PBP6. The red-colored hydrogen bonds drawn to the (scissile) amide carbonyl of the penultimate d-Ala residue indicates its occupancy of the oxyanion hole of the active site.