Figure 2.

Role of SORL1 in transmembrane sorting of APP. The green arrows track re-entry of APP from the cell surface when SORL1 is present. The red arrows show that, when SORL1 is absent, more APP moves into domains such as the late endosome/lysosome, where the black arrows show how it is subsequently cut by beta-secretase (BACE1) and gamma-secretase (PS1 γ-sec), generating the neurotoxic amyloid beta-peptide (Aβ). [Illustration adapted from Rogaeva et al.[89]]