Table 1.
List of proteins that interact with SRCs
| Categories | Functional consequence | Method of detection | References |
|---|---|---|---|
| Transcription factors | |||
| Nuclear receptors | activation | Co-IP, in vitro | 150, 151 |
| AhR/ARNT | activation | Co-IP, in vitro | 152–154 |
| AP-1 | activation | Yeast 2-hybrid, in vitro | 155 |
| Brn-3 | activation | Co-IP | 156 |
| β-catenin | activation | Mammalian 2-hybrid, in vitro | 157 |
| c-Ets | activation | Co-IP | 158 |
| E2F1 | activation | Co-IP, in vitro | 135 |
| HNF4 | activation | Yeast 2-hybrid | 159, 160 |
| IRF3 | activation | Yeast 2-hybrid | 161 |
| MEF-2C | activation | Mammalian 2-hybrid, Co-IP, in vitro | 18 |
| NF-κB | activation | Co-IP | 162 |
| Smad3 | activation | Co-IP, mammalian 1-hybrid | 163 |
| Tat | activation | Co-IP, in vitro | 164 |
| TEF-4 | activation | Yeast 2-hybrid, in vitro | 17 |
| TTF1 | activation | in vitro | 165 |
| Oncogene/Tumor suppressor | |||
| HPV E7 | suppression | Co-IP, in vitro | 166 |
| p53 | activation | in vitro | 167 |
| Rb | activation | Co-IP, in vitro | 168 |
| Kinase/Phosphatase | |||
| aPKC | phosphorylation, stabilization | Co-IP | 56 |
| c-Abl | phosphoryaltion, activation | Co-IP | 50 |
| GSK3 | phosphorylation, activation, degradation | enzyme-substrate interaction | 54 |
| IKK | phosphorylation, activation | Co-IP | 61 |
| MAPK | phosphorylation, activation | enzyme-substrate interaction | 42, 69 |
| PDXP | dephosphorylation, suppression | enzyme-substrate interaction | 55 |
| PKA | phosphorylation, activation | enzyme-substrate interaction | 43, 169 |
| PP1 | dephosphorylation, stabilization | enzyme-substrate interaction | 55 |
| PP2A | dephosphorylation, suppression | enzyme-substrate interaction | 55 |
| Ub/Sumo enzymes | |||
| ARIP3/PIASxα | sumoylation, activation | in vitro | 74 |
| E6AP | ubiquitination, degradation | Co-IP, in vitro | 170 |
| Fbw7 | ubiquitination, activation, degradation | Co-IP | 54 |
| UBCH7 | activation | Co-IP, in vitro | 171 |
| Coregulators | |||
| ANCOS | suppression | Yeast 2-hybrid, Co-IP, in vitro | 172 |
| ASC | activation | Yeast 2-hybrid, in vitro | 173 |
| CARM1 | activation, methylation, suppression | Yeast 2-hybrid, Co-IP | 174 |
| CoCoA | activation | Co-IP, in vitro | 15 |
| GAC63 | activation | Co-IP, in vitro | 14 |
| GCN5 | activation | Co-IP, yeast 2-hybrid | 23 |
| MMS19 | activation | Yeast 2-hybrid, in vitro | 175 |
| p300/CBP | activation, acetylation, suppression | Co-IP, in vitro | 35 |
| PGC1 | activation | in vitro | 142 |
| Others | |||
| Cyclin T1 | activation | in vitro | 164 |
| FLASH | activation, suppression | Yeast 2-hybrid, in vitro | 176, 177 |
| GAS | activation | in vitro | 178 |
| JAB1 | activation | Yeast 2-hybrid, in vitro | 179 |
| Pin1 | activation, degradation | in vitro | 180 |
| REGγ | degradation | Co-IP | 77 |
| SRA | activation | IP | 181 |
| TIA, TIAR | translational inhibition | Co-IP, in vitro | 63 |
This is an incomplete list of SRC interactive proteins representing distinct categories. Co-IP, coimmunoprecipitation; IP, immunoprecipitation; in vitro, in vitro protein-protein interaction assay; AhR/ARNT, aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator; AP-1, activator protein 1; Brn-3, POU domain, class 4, transcription factor 1; c-Ets, mammalian protooncogene homologue of the avian v-ets; E2F1, E2F transcription factor 1; HNF4, hepatic nuclear factor 4; IRF3, interferon regulatory factor 3; MEF-2C, myelin basic protein expression factor 2; NF-κB, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Smad3, MAD homolog 3; Tat, Human immunodeficiency virus transactivator protein; TEF-4, transcriptional enhancer factor family of transcription factors; TTF1, thyroid transcription factor 1; p53, transformation related protein 53; Rb, retinoblastoma 1; APKC, atypical protein kinase C; c-Abl, c-abl oncogene 1, receptor tyrosine kinase; GSK3, glycogen synthase kinase 3; IKK, inhibitor of kappaB kinase; MAPK, mitogen-activated protein kinase; PDXP, pyridoxal (pyridoxine, vitamin B6) phosphatase; PKA, protein kinase A; PP1, protein phosphatase 1; PP2A, protein phosphatase 2; ARIP3/PIASxα, protein inhibitor of activated STAT 2; E6AP, ubiquitin protein ligase E3A; Fbw7, F-box and WD-40 domain protein 7; UBCH7, ubiquitin-conjugating enzyme E2L 3; ANCOS, ankyrin repeats containing cofactors; ASC, Activating signal cointegrator 1; CARM1, coactivator-associated arginine methyltransferase 1; CoCoA, calcium binding and coiled coil domain 1; GAC63, solute carrier family 30 (zinc transporter), member 9; GCN5, lysine acetyltransferase 2A; MMS19, MET18 S. cerevisiae; p300/CBP, E1A binding protein p300/CREB binding protein; PGC1, peroxisome proliferative activated receptor, gamma, coactivator 1; FLASH, caspase 8 associated protein 2; GAS, glutamate-rich coactivator interacting with SRC1; JAB1, JUN activation binding protein 1; Pin1, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; REGγ, proteaseome (prosome, macropain) 28 subunit, 3; SRA, steroid receptor RNA activator; TIA, TIAR, T-cell intracellular antigen 1 and related protein.