Figure 4. Pharmacological inhibition of IL-1β secretion by Vitamin D3 inhibits the prosurvival function of macrophages.
A: The amount of apoptosis was determined in HCT116 cells treated with TRAIL under indicated conditions. Error bars were derived from 2 independent experiments. B: The effect of vitamin D3 on TRAIL-induced activation of caspases and the cleavage of PARP and β-catenin was determined by immunoblotting.