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A: HCT116 and Hke-3 cells were transfected with NSP or Snail specific siRNA and were treated with TRAIL in the absence or the presence of macrophages or IL-1β as indicated. Data represent the average of two independent experiments. B and C: Silencing of IL-1β or STAT1 (B) in macrophages, or treatment with vitamin D3 (C) abrogates the ability of macrophages to stabilize Snail in colon cancer cells.
