Table 3.
Trial ID | Total score | Blinding | Outcome measure: blood pressure | Loss to follow-up | Funding source | Compliance; other chocolate diary |
---|---|---|---|---|---|---|
Scores given | 1: choc + control blinded | 1: Primary | 1: < 20% | 1: Sponsor not involved in data collection, analysis | 1: Compl assessed; no sign diff between groups | |
0.5: control blinded | 0.5: Secondary | 0: ≥ 20% | 0: Sponsor involved | 1: Compl assessed, sign diff included in analysis | ||
0: No blinding | 0: Compl not assessed | |||||
Taubert et al. [10] | 4 | 0: dark/white | 1 | 1: none | 1 | 1 |
Murphy et al. [15] | 3.5 | 1: cocoa tablets | 0.5 | 1: 9.5% (4 of 42) | 0: supported by Mars | 1: tablet count, 7 day weight food records x2 |
Engler et al. [11] | 5 | 1: flav bar matched | 1 | 1: none | 1 | 1 |
Fraga et al. [12] | 2.5 | 0: dark/white | 1 | 1: 3.6% (1 of 28) | 0: 3 authors from Mars | 0.5: reported what consumed, no diary |
Grassi et al. [13] | 3.5 | 0: dark/white | 1 | 1: none | 0.5: unclear | 1: daily diary |
Grassi et al. [13] | 3.5 | 0: dark/white | 1 | 1: none | 0.5: unclear | 1: daily diary |
Taubert et al. [16] | 4 | 0: dark/white | 1 | 1: none | 1 | 1: food diary |
Crews et al. [17] | 2.5 | 0.5: flav drink; > 50% assumed correct group they were in | 1 | 0.5: 11% (11 of 101) | 0.5: independent industry research grant, supplier | 0: not reported |
Grassi et al. [18] | 3.5 | 0: dark/white | 1 | 1: none | 0.5: unclear | 1: diary |
Muniyappa et al. [20] | 3 | 1: flav drink; blinding assessed ok | 1 | 0: 31% (9 of 29) | 1 | 0: not reported |
Davison et al. [21] | 3 | 1: flav drink | 1 | 0: 21% (14 of 65) | 0: Mars Financial support | 1: diet + background exercise |
Davison et al. [21] | 3 | 1: flav drink | 1 | 0: 21% (14 of 65) | 0: Mars Financial support | 1: diet + background exercise |
Shiina et al. [22] | 2 | 0: dark/white | 0 | 1: none | 1 | 0 |
Ried et al. [23] | 4.5 | 0.5: control blinded | 1 | 1: 8% (3 of 39) | 1 | 1: diary |
Monagas et al. [24] | 3.5 | 0: cocoa powder in milk/milk | 0.5 | 1: none | 1 | 1: diet monitoring (3-day food questionnaires x3) |
All 15 trial arms were adequately randomised.
Choc, chocolate; compl, compliance; flav, flavanol; sign diff, significant difference;