Figure 6. Structural details of HuPrP(90–231, M129, Q212P) (A, C, E) and WT protein (B, D, F).

(A) Carton presentation of α₂, α₃ and α₄ helices with mutual orientation of Phe175 and Gln217 in the Q212P mutant. (B) Carton presentation of α₂ and α₃ helices with mutual orientation of Phe175 and Gln217 in the WT protein. (C) The mutual orientation of α₂ and α₃ helices with indicated inter-helical angle in Q212P mutant. (D) The mutual orientation of α₂ and α₃ helices with indicated inter-helical angle in WT protein. (E) Structural organization of β₂-α₂ loop and α₃ and α₄ helices in Q212P mutant. (F) Structural organization of β₂-α₂ loop and α₃ helix in WT protein.