Figure 1. Overall Study Design.

We developed cellular pathway expression summaries and tested the relationship of each to pathological subtypes of lung adenocarcinoma (AD). We also tested each pathway's association with survival. Because the cellular pathways are driving the pathological differences, the relationship between pathology and prognosis is secondary to the relationship between the cellular pathway and prognosis (indicated by a thinner line with both component colors). We also directly tested the relationship between pathology and prognosis to examine the need for molecular information.