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. 2010 Jul 22;6(7):e1001032. doi: 10.1371/journal.pgen.1001032

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Spontaneous Brc1-GFP foci are reduced in clr4Δ mutants. Live cell microscopy of Brc1-GFP overexpressed using the nmt promoter in wild type, htaAQ, and clr4Δ cells. There is no foci formation in the htaAQ mutant. Graph shows quantitated foci in the indicated strains. (B) Brc1 binds at γH2A sites, and Brc1 association with the telomeres and centromeres is reduced in clr4Δ mutants. ChIP to sites of Brc1-GFP overexpressed from the nmt promoter at γH2A-sites in the indicated strains. Cell cultures were asynchronous. Primer locations were described in Figure 2C and Figure 5B.