Figure 3. Effects of NR2B and NR2A-selective antagonists on LFS paring-induced LTP in Ras-GRF2 knock-out mice.

A. Hippocampal brain slices from Ras-GRF2 knockout mice were perfused throughout the experiments with 0.5 µM of the NR2B selective inhibitor Ro. LFS paring-induced LTP was then measured. B. Hippocampal brain slices from Ras-GRF2 knockout mice were perfused throughout the experiments with 50 ηM of the NR2A selective inhibitor NVP. LFS paring-induced LTP was then measured. Inset: Averaged EPSCs before and after LFS paring in the presence of Ro (left) and NVP (right). Calibration: horizontal, 50 ms; vertical, 50 pA.