Figure 5. The effects of MEK and PI3-kinase inhibitors on LFS induced LTP in WT mice.

A LTP was measured in cells in which SL327 (100 µM) was present in recording electrode solution (black filled circles; 0.2% DMSO; n = 7). Tissues were bathed in either 0.5 µM Ro (red filled squares; n = 5) or 50 ηM NVP (green filled triangles; n = 7). B LTP was measured in cells in which LY294002 (Ly) (100 µM) was included in the recording electrode solution (black filled circles; n = 5). These tissues were also bathed in either 0.5µM Ro (red filled squares; n = 5) or 50 ηM NVP (green filled triangles; n = 7). C. Summary graph showing the effects of these drugs on the LTP.