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. 2010 Jul 22;5(7):e11732. doi: 10.1371/journal.pone.0011732

Figure 6. Model of Ras-GRF2 dependent and Ras-GRF independent LTP in hippocampal CA1 pyramidal neurons.

Figure 6

Both NR2A and NR2B-containing NMDARs can produce LTP. However, GRF proteins only make a major contribution to LTP through NR2A-containing receptor signaling through GRF2. Although GRF1 binds to NR2B receptors and contributes to LTD, it does not contribute significantly to NR2B induced LTP. Moreover, like GRF2, Erk mediates only NR2A induced LTP, while PI3K mediates both NR2A and NR2B induced LTP.