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. 2010 Jul 22;6(7):e1000862. doi: 10.1371/journal.pcbi.1000862

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Harari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) PhoP BSs detected in Y. pestis promoters based on E. coli K-12 and S. typhimurium (lefts panel). Submotifs reconstructed from PhoP targets detected in Yersinia [44] (middle panel). Joined submotifs from E. coli, Salmonella, and Yersinia PhoP BSs (right panel). B) Promoter architectures and submotifs identified in PhoP-activated promoters in Yersinia. Schematic based on DNase I footprinting analysis [58] of the promoter regions for selected genes (blue: highest affinity; violet: lower affinity sites). BSs overlapping or downstream the TSS correspond to repression sites. Close and medium distances between PhoP BSs and the RNAP BSs are highlighted by arrows.