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Dose escalation scheme. The starting dose level for all cohorts was dose level 1. Bold indicates the MTD, when determined. In cohort A, one of the patients experiencing DLT did not complete cycle 1 and was replaced
| Cohort | Dose level |
Dose (mg/m2) |
No. of patients |
DLTs | ||
|---|---|---|---|---|---|---|
| 17-AAG | Gemcitabine | Cisplatin | ||||
| A | 1 | 154 | 750 | 40 | 6 | 0 |
| 2 | 154 | 1,000 | 40 | 3 | 3 (1) | |
| B | 0 | 154 | 750 | 40 | 3 | 1 |
| 1 | 231 | 750 | 40 | 3 | 2 | |
| C | 1 | 154 | 750 | 6 | 1 | |
| 2 | 231 | 750 | 3 | 2 | ||
| D | 0 | 154 | 30 | 3 | 0 | |
| 1 | 154 | 40 | 3 | 2 | ||
| E | 1 | 300 | 750 | 20 | 3 | 2 |
