Table 5.
Factor | Level | # of patients | HSP90 |
HSP70 |
ILK |
|||
---|---|---|---|---|---|---|---|---|
Mean | p-value | Mean | p-value | Mean | p-value | |||
DLT | No | 24 | 100.4 | 140.5 | 102.3 | |||
Yes | 12 | 91.7 | 0.135 | 145.4 | 0.662 | 100.8 | 0.872 | |
Response | PD+TE+NA | 19 | 103.2 | 146.6 | 102.2 | |||
PR+SD | 17 | 88.9 | 0.013* | 139.3 | 0.491 | 100.9 | 0.880 | |
17-AAG dose | 154 mg/m^2 | 27 | 88.1 | 127.3 | 99.8 | |||
231 mg/m^2 | 6 | 100.0 | 0.190 | 149.2 | 0.232 | 99.9 | 1.000 | |
300 mg/m^2 | 3 | 100.1 | 0.318 | 152.3 | 0.278 | 104.9 | 0.905 | |
Time | Pre-17AAG | 36 | 103.2 | 110.5 | 100.8 | |||
6 h post | 36 | 97.0 | 0.479 | 145.8 | 0.003* | 99.9 | 0.993 | |
25 h post | 36 | 88.0 | 0.016* | 172.6 | <.0001* | 104.0 | 0.925 |
p<0.05