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Effect of azithromycin on GCF IL-1β and VEGF content. Arrows indicate the times azithromycin was administered. Data represent the mean (± SEM) recovery from samples obtained from 12 separate maxillary interproximal sites. The treatment effects on IL-1β and VEGF content were significant (P < 0.001, repeated-measures ANOVA). Significant differences from baseline IL-1β are denoted by *, and significant differences from baseline VEGF content are denoted by # (P < 0.05, Holm-Sidak test).
