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. 2010 Aug;2(8):a002055. doi: 10.1101/cshperspect.a002055

Figure 5.

Figure 5.

A Robo code for lateral positioning. (A) Longitudinal tracts are divided into three zones, with axons expressing Robo1 in the medial zone, axons expressing Robo1 and Robo3 in the intermediate zone, and axons expressing all three Robos in the lateral zone. (B) Confocal image of a nerve cord, stained for all axons (blue), Robo3 (green), and Robo2 (red). Image in B is from Rajagopalan et al. 2000b. (C) In rodent spinal cord, commissural axons expressing Robo1 project in the ventral funiculus after midline crossing, those expressing Robo2 take a more lateral position in the lateral funiculus and those expressing both occupy the longitudinal tracts in between. (D) Fluorescence images of Robo1 and Robo2 staining in the ventral and lateral funiculus. Image in D is from Long et al. 2004.