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. 2010 Aug;2(8):a003186. doi: 10.1101/cshperspect.a003186

Figure 1.

Figure 1.

EGF-family peptides and ErbB Receptors. The four ErbB receptors are shown: (1) EGFR, (2) ErbB2, (3) ErbB3, and (4) ErbB4. The EGF-family peptides bind specific ErbB receptors: EGF, TGF-α,AR, and EPG bind EGFR; BTC, HB-EGF, EPR have dual specificity, binding both EGFR and ErbB4; NRG-1 and NRG-2 bind ErbB3 and ErbB4; NRG-3 and NRG-4 bind ErbB4 (Hynes and Lane 2005). Various roles for specific ligands (boxed in red) and all the ErbB receptors have been described in normal mammary gland development. In breast cancer, overexpressed ErbB2 together with ErbB3 function as a unit to drive proliferation of specific subsets of tumors (Holbro et al. 2003). EGFR is overexpressed in 30%–60% of basal-like breast cancers. See text for more information.