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Parallel mechanisms lead to yeast telomere attachment at the nuclear envelope. At different stages of the cell cycle the telomere associated proteins mediate different contacts with inner nuclear membrane components. The Sir4-PAD domain binds the Esc1 C terminus, as well as yKu80 and Mps3. yKu80 binds telomerase, which also associates with Mps3 in S phase through Est1. There is an unidentified anchor for yKu in G1 phase that is neither Esc1- nor Mps3-dependent.
