Figure 1.

p53 lies at the center of a complex signalling network. In response to various inputs (top of figure), the p53 protein becomes stabilized. On stabilization of p53, various transcriptional outputs can be realized which may be determined by the strength of the p53 RE, the posttranslational modification status of p53, specific p53 binding partners, and the epigenetic landscape of the target gene promoter, among others. The transcriptional output of p53 is responsible for determining which cellular process(es) occur in response distinct genotoxic insults.