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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Hepatology. 2010 Apr;51(4):1291–1301. doi: 10.1002/hep.23471

Figure 7.

Figure 7

Effects of in vivo MafG and c-Maf knockdown in BDL mice. Mice were treated with lentivirus carrying scrambled (SC), MafG, c-Maf or both MafG and c-Maf siRNA. In part A, pilot experiment showed transduction efficiency as estimated by % hepatocytes that were positive for GFP to fall significantly by day 7 following a single injection. However, transduction efficiency was excellent even at day 14 with repeated injections (day 6 and 10). Mice were subjected to BDL or sham surgery and injected with lentivirus at the time of BDL, on day 6 and 10 and sacrificed on day 14 for determination of necrosis by H&E (B), apoptosis by TUNEL (C) and fibrosis by Sirius red staining (D). See Table I for quantitation of these (100× for A and B and C). See Methods for details.