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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Cell Stem Cell. 2010 Jul 2;7(1):127–133. doi: 10.1016/j.stem.2010.05.021

Figure 1.

Figure 1

Orthotopic transplantation of Kras and Kras;p53-flox tumor cells recapitulates the primary tumor phenotype.

(A) Cartoon of the transplantation scheme used to assay lung tumor-propagating cells (TPCs) through serial transplantation. (B) H&E staining of primary (left) and secondary (right) Kras lung adenocarcinomas showing similar pathological grade, nuclear features, and general tumor architecture. (C) H&E staining of primary (left) and secondary (right) Kras;p53-flox lung tumors showing similar histopathological characteristics of advanced adenocarcinoma, including pleomorphic nuclei and rare giant cells. All images, 200× magnification. Scale bar = 100μM.