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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Epilepsia. 2010 Jul;51(Suppl 3):171–177. doi: 10.1111/j.1528-1167.2010.02635.x

Figure 1. Systems biology of epilepsy project (SBEP).

Figure 1

From our epilepsy surgery program, we have developed a relational database that allows the integration of various types of data starting with clinical information specific to a given patients undergoing surgery and leading the identification of biomarkers (diagnostics) and drug targets. All of our patients undergo a 2-stage surgery where subdural recording electrodes are placed directly on the neocortex in the first stage, and tissue is resected to treat the seizures based on those recordings in the second stage. All of the clinical information is stored together with electrode location specific data including electrophysiology for all electrodes, and histopathology and high-throughput molecular data such as genomic, proteomics, and metabolomics for electrodes under which tissue was resected. A major goal of this work is to test potential drug targets identified from these systems in animal models in order to develop new therapeutics.