Table 2.

Heat-induced changes in tumor oxygenation.

References	Tumor Type	Site	Tumor oxygenation
(109)	C3H mammary tumor	Mouse leg (i.m.)	pO2 increased at < 41 °C and decreased at > 42°C.
(110)	S-180 tumor	Mouse limb (s.c.)	pO2 increased during heating at 41 °C for 30 min. pO2 increased at 42°C for 30 min, decreased after heating, but increased again 14-18 hr after heating. pO2decreased at 45°C for 30 min and failed to recover after heating.,
(111)	DS carcinoma	Rat foot	Oxygenation (Hb O2 in blood vessels) peaked at 39.5°C and decreased at 42°C.
(74)	R3230 AC tumor	Rat leg (s.c.)	pO2 increased during and 12-15 min after heating at 40.5-43.5°C for 30 min. pO2 increased during and 12-15 min after heating at 40.5-41.5°C for 60 min but decreased during heating at 43°C for 60 min
(77)	R3230 AC tumor	Rat leg (s.c.)	pO2 decreased during heating at 42.5°C for 60 min but increased 24 hr after heating pO2 decreased during and 24 hr after heating at 43.5°C for 60 min
(85)	C3H mammary tumor	Mouse flank or leg (s.c.)	pO2 increased 24 hr after heating at 43.5°C for 60 min. pO2 decreased 4 hr after heating at 43.5°C for 120 min. Heat-induced changes in pO2 depend on tumor site because pO2 in the legs did not increase by heating.
(119)	SCK mammary carcinoma	Mouse leg (s.c.)	pO2 increased during and 12-15 min after heating at 41.5°C for 60 min
(115)	Human soft tissue sarcoma	Human extremity	pO2 increased I day after first hyperthermia