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. 2010 Aug;33(8):1865–1871. doi: 10.2337/dc10-0641

Figure 3.

Figure 3

Metabolic syndrome (MetS) is a risk factor for both type 2 diabetes (T2D) and CVD. A: Shows that among men in FHS, the 7- to 11-year risk for CVD increases from 1.5 for those with one or two MetS risk factors (RFs) to 4.0 for those with three or more (that is, with MetS) relative to those with no MetS risk factors, even after accounting for other CVD–specific risk factors. The bars in the figure represent the odds ratio and its 95% confidence bounds. The relative risk for CVD is 2.9 comparing MetS vs. no MetS. Risk for type 2 diabetes increases from 4.2 for men with one or two MetS risk factors to 24 for those with MetS relative to those with no MetS risk factors, even after accounting for other type 2 diabetes–specific risk factors. The relative risk for type 2 diabetes is 6.9 comparing MetS vs. no MetS. Patterns are similar for FHS women. Risk rises steadily in a dose-response relationship as the number of component traits increases and is increased regardless of which of the various heterogeneous combinations of specific traits are present, and even in the absence of impaired glycemia (B) (adapted from Wilson et al. [10]). BP, blood pressure; FG, fasting glucose; TG, triglycerides.