Table 1.

Associations of LDLR 3UTR haplotypes with statin-mediated percent change inlipidsin African-Americans.

		N	LDL-cholesterol	Total cholesterol	apoB†	nonHDLC†
LDLR L1	Noncarriers	286	−35.7±4.7	−24.8±3.4	−27.2±0.9	−33.8±4.4
	Carriers	49	−39.3±5.1	−27.5±3.7	−29.3±2.0	−37.2±4.8
	q-value*		0.23	0.11	0.36	0.23
LDLR L2	Noncarriers	223	−35.7±4.7	−24.6±3.4	−26.9±1.0	−33.6±4.4
	Carriers	112	−37.2±4.9	−26.7±3.5	−29.0±1.4	−35.7±4.5
	q-value*		0.53	0.11	0.22	0.28
LDLR L3	Noncarriers	140	−35.6±4.8	−24.7±3.5	−25.9±1.2	−33.5±4.5
	Carriers	195	−36.2±4.7	−25.2±3.4	−28.8±1.0	−34.4±4.4
	q-value*		0.57	0.44	0.10	0.50
LDLR L4	Noncarriers	256	−36.1±4.7	−25.0±3.4	−27.7±0.9	−34.2±4.4
	Carriers	79	−35.7±4.9	−25.6±3.6	−27.4±1.6	−33.8±4.6
	q-value*		0.58	0.44	0.71	0.66
LDLR L5	Noncarriers	207	−36.9±4.7	−25.9±3.4	−29.8±1.0	−35.2±4.4
	Carriers	128	−33.5±4.8	−22.8±3.5	−23.9±1.3	−31.1±4.5
	q-value*		0.12	0.03	0.001	0.03
LDLR L6	Noncarriers	320	−36.1±4.7	−25.2±3.4	−28.0±0.9	−34.2±4.4
	Carriers	15	−33.7±5.9	−21.2±4.2	−20.9±3.5	−31.1±5.5
	q-value*		0.56	0.16	0.10	0.42

^*Associations were adjusted for age, sex, BMI, smoking status and HMGCR H2/H7 haplotype. Q-values represent P-values following adjustment for multiple testing within each phenotype.

^†Abbreviations: apoB; apolipoprotein B; nonHDLC, nonHDL-cholesterol.