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. Author manuscript; available in PMC: 2010 Jul 23.
Published in final edited form as: J Immunol. 2008 Apr 1;180(7):5101–5108. doi: 10.4049/jimmunol.180.7.5101

Figure 5. Accumulation of Ly6Chi monocytes is correlated with the frequency of anti-Sm/RNP autoantibodies and upregulation of ISG expression.

Figure 5

A) Flow cytometry of peritoneal cells in wild-type 129Sv mice treated with n-hexadecane (2 weeks) or squalene (2 weeks). Boxes indicate Ly6Chi immature monocytes. Correlation of the levels of Ly6Chi monocyte accumulation with B) the frequency of anti-Sm/RNP autoantibodies and C) ISG expression induced by TMPD, n-hexadecane (HEX), squalene (SQ), and mineral oil (MO) and PBS. Autoantibody frequencies represent the mean of >10 mice per group from previous studies. Percentage of Ly6Chi monocytes and ISG expression index represent the mean of 4 mice. Error bars indicate s.d. ISG expression index was calculated as follows: mean relative expression of (Mx-1 + MCP + IP-10)/3.