. 2010 Jul 5;11:61. doi: 10.1186/1471-2156-11-61

Table 1.

SNP and SNP-set associations with measures of mathematics at age 10.

			Web Measures								Teacher-rated Measures

	Mathematics composite at 10		Web total		Understanding number		Non-numerical processes		Computation and knowledge		Teacher total		Using and applying		Number and algebra		Shapes, space & measures
	Cor	N	Cor	N	Cor	N	Cor	N	Cor	N	Cor	N	Cor	N	Cor	N	Cor	N

rs11225308	0.074**	2184	0.077**	1723	0.064**	1723	0.072**	1723	0.066**	1723	0.055**	1795	0.059**	1811	0.043*	1815	0.048*	1800

rs363449	0.069**	2182	0.070**	1703	0.057**	1703	0.041*	1703	0.075**	1703	0.067**	1802	0.070**	1820	0.064**	1823	0.063**	1807

rs17278234	0.067**	2188	0.050*	1708	0.059**	1708	0.038*	1708	0.033	1708	0.062**	1805	0.052*	1823	0.065**	1826	0.064**	1810

10-SNP set	0.167**	1888	0.145**	1486	0.151**	1486	0.107**	1486	0.119**	1486	0.145**	1551	0.132**	1567	0.146**	1571	0.141**	1556

43-SNP set	0.164**	1893	0.149**	1490	0.144**	1490	0.113**	1490	0.127**	1490	0.145**	1553	0.134**	1569	0.145**	1573	0.140**	1558

r_p	NA	NA	0.911**	1854	0.822**	1845	0.714**	1854	0.822**	1854	0.915**	1933	0.872**	1967	0.880**	1970	0.876**	1957

Results of the tests of association of components of the mathematics composite at age 10 with rs11225308, rs363449, rs17278234, and the 10- and 43-SNP sets previously associated with the mathematics composite score. Associations are presented as correlations between the quantitative traits and additive genotypic values (as 0, 1, and 2 'increasing' alleles) for SNPs and additive SNP scores for SNP sets. Mathematics composite at 10 = the originally associated measure of mathematics at age 10; Web total = total web-test score at age 10; Understanding Number, Non-numerical Processes and Computation and Knowledge = three components of the web-test; Teacher total = teacher rating of mathematics at age 10; Using and Applying, Number and Algebra and Shapes, space and measures = three components of the teacher rating; Cor = Pearson product-moment correlations (p-values included in italics); N = size of sample analysed; r_p= phenotypic correlation with mathematic composite score at age 10. One-tailed p-values were generated for all SNP-associations. * = nominally significant associations (p < 0.05). ** = associations withstanding Bonferroni testing for the five (three individual SNP and two SNP-set) association tests conducted simultaneously for each measure (p < 0.01).