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. Author manuscript; available in PMC: 2010 Jul 23.
Published in final edited form as: Physiol Rev. 2008 Oct;88(4):1243–1276. doi: 10.1152/physrev.00031.2007

TABLE 1.

Properties of human SOD isoenzymes

Property SOD1 SOD2 SOD3
Cellular location Cytosol and mitochondrial IMS Mitochondrial matrix Extracellular
Metal/monomer 1 Cu, 1 Zn 1 Mn 1 Cu, 1 Zn
Molecular mass, kDa 32.5 24.7 30
Subunit Dimer Tetramer Tetramer
Inhibition by CN− Yes No Yes
Inhibition by H2O2 Yes Yes Yes
Rate constant for reaction with O2− 0.62 × 109 1.2 × 109 0.72 × 109

IMS, intermembrane space. Data from Hearn et al. (144) and Suzuki et al. (385).