Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1961 Dec;40(12):2143–2152. doi: 10.1172/JCI104440

IRON AND PROTEIN KINETICS STUDIED BY MEANS OF DOUBLY LABELED HUMAN CRYSTALLINE TRANSFERRIN*

Jay H Katz 1
PMCID: PMC290922  PMID: 14454385

Full text

PDF
2148

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APT L., POLLYCOVE M., ROSS J. F. Idiopathic pulmonary hemosiderosis; a study of the anemia and iron distribution using radioiron and radiochromium. J Clin Invest. 1957 Jul;36(7):1150–1159. doi: 10.1172/JCI103511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AZARI P. R., FEENEY R. E. Resistance of metal complexes of conalbumin and transferrin to proteolysis and to thermal denaturation. J Biol Chem. 1958 May;232(1):293–302. [PubMed] [Google Scholar]
  3. AZARI P. R., FEENEY R. E. The resistances of conalbumin and its iron complex to physical and chemical treatments. Arch Biochem Biophys. 1961 Jan;92:44–52. doi: 10.1016/0003-9861(61)90216-8. [DOI] [PubMed] [Google Scholar]
  4. BOTHWELL T. H., HURTADO A. V., DONOHUE D. M., FINCH C. A. Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood. 1957 May;12(5):409–427. [PubMed] [Google Scholar]
  5. BUSH J. A., ASHENBRUCKER H., CARTWRIGHT G. E., WINTROBE M. M. The anemia of infection. XX. The kinetics of iron metabolism in the anemia associated with chronic infection. J Clin Invest. 1956 Jan;35(1):89–97. doi: 10.1172/JCI103255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CARTWRIGHT G. E., GUBLER C. J., WINTROBE M. M. The anemia of infection. XII. The effect of turpentine and colloidal thorium dioxide on the plasma iron and plasma copper of dogs. J Biol Chem. 1950 Jun;184(2):579–587. [PubMed] [Google Scholar]
  7. ELGEE N. J., WILLIAMS R. H., LEE N. D. Distribution and degradation studies with insulin I131. J Clin Invest. 1954 Sep;33(9):1252–1260. doi: 10.1172/JCI103000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FRAENKEL-CONRAT H., FEENEY R. E. The metal-binding activity of conalbumin. Arch Biochem. 1950 Nov;29(1):101–113. [PubMed] [Google Scholar]
  9. GITIL D., LANDING B. H., WHIPPLE A. The localization of homolgous plasma proteins in the tissues of young human beings as demonstrated with fluorescent antibodies. J Exp Med. 1953 Feb 1;97(2):163–176. doi: 10.1084/jem.97.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GITLIN D., CORNWELL D. G., NAKASATO D., ONCLEY J. L., HUGHES W. L., Jr, JANEWAY C. A. Studies on the metabolism of plasma proteins in the nephrotic syndrome. II. The lipoproteins. J Clin Invest. 1958 Feb;37(2):172–184. doi: 10.1172/JCI103596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GITLIN D., JANEWAY C. A., FARR L. E. Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. J Clin Invest. 1956 Jan;35(1):44–56. doi: 10.1172/JCI103251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GOODMAN M., NEWMAN H. S., RAMSEY D. S. The use of chicken antiserum for the rapid determination of plasma protein components. III. The assay of human serum transferrin. J Lab Clin Med. 1958 May;51(5):814–823. [PubMed] [Google Scholar]
  13. GOODMAN M., POULIK E., POULIK M. D. Variations in the serum specificities of higher primates detected by two-dimensional starch-gel electrophoresis. Nature. 1960 Oct 1;188:78–79. doi: 10.1038/188078b0. [DOI] [PubMed] [Google Scholar]
  14. HINE G. J., JAGGER P. I., BURROWS B. A. Measurement of body radioactivity for studies of sodium metabolism. J Lab Clin Med. 1960 Mar;55:476–485. [PubMed] [Google Scholar]
  15. HUFF R. L., HENNESSY T. G., AUSTIN R. E., GARCIA J. F., ROBERTS B. M., LAWRENCE J. H. Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J Clin Invest. 1950 Aug;29(8):1041–1052. doi: 10.1172/JCI102335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. INMAN J. K., CORYELL F. C., McCALL K. B., SGOURIS J. T., ANDERSON H. D. A large-scale method for the purification of human transferrin. Vox Sang. 1961 Jan;6:34–52. doi: 10.1111/j.1423-0410.1961.tb03134.x. [DOI] [PubMed] [Google Scholar]
  17. JANDL J. H., INMAN J. K., SIMMONS R. L., ALLEN D. W. Transfer of iron from serum iron-binding protein to human reticulocytes. J Clin Invest. 1959 Jan 1;38(1 Pt 1):161–185. doi: 10.1172/JCI103786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KORMAN S. Iron metabolism in man. Ann N Y Acad Sci. 1960 Aug 18;88:460–473. doi: 10.1111/j.1749-6632.1960.tb20043.x. [DOI] [PubMed] [Google Scholar]
  19. LAURELL C. B. What is the function of transferrin in plasma? Blood. 1951 Feb;6(2):183–187. [PubMed] [Google Scholar]
  20. MCFARLANE A. S. Labelling of plasma proteins with radioactive iodine. Biochem J. 1956 Jan;62(1):135–143. doi: 10.1042/bj0620135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MITCHELL J., HALDEN E. R., JONES F., BRYAN S., STIRMAN J. A., MUIRHEAD E. E. Lowering of transferrin during iron absorption in iron deficiency. J Lab Clin Med. 1960 Oct;56:555–569. [PubMed] [Google Scholar]
  22. McMENAMY R. H., LUND C. C., ONCLEY J. L. Unbound amino acid concentrations in human blood plasmas. J Clin Invest. 1957 Dec;36(12):1672–1679. doi: 10.1172/JCI103568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. OUCHTERLONY O. Diffusion-in-gel methods for immunological analysis. Prog Allergy. 1958;5:1–78. [PubMed] [Google Scholar]
  24. PEASE D. C. An electron microscopic study of red bone marrow. Blood. 1956 Jun;11(6):501–526. [PubMed] [Google Scholar]
  25. PETERS T., GIOVANNIELLO T. J. A note on the serum iron determination described by Peters, Giovanniello, Apt, and Ross. J Lab Clin Med. 1958 Mar;51(3):494–494. [PubMed] [Google Scholar]
  26. PETERS T., GIOVANNIELLO T. J., APT L., ROSS J. F. A new method for the determination of serum iron-binding capacity. I. J Lab Clin Med. 1956 Aug;48(2):274–279. [PubMed] [Google Scholar]
  27. PETERS T., GIOVANNIELLO T. J., APT L., ROSS J. F. A simple improved method for the determination of serum iron. II. J Lab Clin Med. 1956 Aug;48(2):280–288. [PubMed] [Google Scholar]
  28. POLLYCOVE M., MORTIMER R. The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects. J Clin Invest. 1961 May;40:753–782. doi: 10.1172/JCI104310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SCHREIBER S. S., BAUMAN A., YALOW R. S., BERSON S. A. Blood volume alterations in congestive heart failure. J Clin Invest. 1954 Apr;33(4):578–586. doi: 10.1172/JCI102929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. SCHULTZ A. L., HAMMARSTEN J. F., HELLER B. I., EBERT R. V. A critical comparison of the T-1824 dye and iodinated albumin methods for plasma volume measurement. J Clin Invest. 1953 Feb;32(2):107–112. doi: 10.1172/JCI102717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. SMITHIES O. An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals. Biochem J. 1959 Mar;71(3):585–587. doi: 10.1042/bj0710585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. SMITHIES O. Third allele at the serum beta-globulin locus in humans. Nature. 1958 Apr 26;181(4617):1203–1204. doi: 10.1038/1811203b0. [DOI] [PubMed] [Google Scholar]
  33. SOLOMON A. K. Equations for tracer experiments. J Clin Invest. 1949 Nov;28(6 Pt 1):1297–1307. doi: 10.1172/JCI102197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. SONENBERG M., MONEY W. L., DORANS J. F., LUCAS V., BOURQUE L. The distribution of radioactivity in the tissues of the rat after the administration of radioactive growth hormone preparations. Endocrinology. 1954 Dec;65(6):709–720. [PubMed] [Google Scholar]
  35. SONENBERG M., MONEY W. L., KESTON A. S., FITZGERALD P. J., GODWIN J. T. Localization of radioactivity after administration of labeled prolactin preparations to the female rat. Endocrinology. 1951 Dec;49(6):709–719. doi: 10.1210/endo-49-6-709. [DOI] [PubMed] [Google Scholar]
  36. STEINFELD J. L., GREENE F. E., TABERN D. L., PATON R. R., FLICK A. L. Degradation of iodinated human serum albumin prepared by various procedures. J Lab Clin Med. 1958 May;51(5):756–766. [PubMed] [Google Scholar]
  37. Schade A. L., Caroline L. An Iron-binding Component in Human Blood Plasma. Science. 1946 Oct 11;104(2702):340–341. doi: 10.1126/science.104.2702.340. [DOI] [PubMed] [Google Scholar]
  38. Surgenor D. M., Koechlin B. A., Strong L. E. CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVII. THE METAL-COMBINING GLOBULIN OF HUMAN PLASMA. J Clin Invest. 1949 Jan;28(1):73–78. doi: 10.1172/JCI102056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. TURNBULL A., GIBLETT E. R. The binding and transport of iron by transferrin variants. J Lab Clin Med. 1961 Mar;57:450–459. [PubMed] [Google Scholar]
  40. WARNER R. C. The metal chelate compounds of proteins. Trans N Y Acad Sci. 1954 Feb;16(4):182–188. doi: 10.1111/j.2164-0947.1954.tb01161.x. [DOI] [PubMed] [Google Scholar]
  41. WEISS L. An electron microscopic study of the vascular sinuses of the bone marrow of the rabbit. Bull Johns Hopkins Hosp. 1961 Mar;108:171–199. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES