Table 1.

Effects of race moderated by age, stage and cohort^a on breast cancer 5-year survival: women diagnosed between 1975 and 1980, and 1990 and 1995 were respectively followed until January 1, 1986 and 2001

Age	1970s 5-year survival cohort			1990s 5-year survival cohort
	n	OR	95% CI	n	OR	95% CI
Race moderated by cohortb
25+	9,967	1.64	1.46, 1.84	16,030	1.94	1.79, 2.16
Race moderated by age and cohortc
<65	6,448	1.60	1.39, 1.84	8,437	2.06	1.85, 2.30
65+	3,519	1.74	1.41, 2.16	7,593	1.79	1.58, 2.04
Race moderated by age, stage and cohortd
Race moderated by age and cohort within node negative diseasec
<65	4,534	1.45	1.21, 1.74	5,074	1.86	1.56, 2.22
65+	2,454	1.40	1.05, 1.85	5,263	1.56	1.31, 1.86
Race moderated by age and cohort within node positive diseasec
<65	1,211	1.61	1.19, 2.19	2,696	2.02	1.69, 2.42
65+	528	1.89	1.12, 3.19	1,657	1.91	1.47, 2.47
Race moderated by age and cohort within metastasized disease
<65	478	1.54	0.79, 3.00	467	2.03	1.11, 3.71
65+	359	1.81	0.78, 4.20	429	1.98	0.93, 4.21

Notes: n = number of incident female breast cancer cases, OR = odds ratio, CI = confidence interval. Main and interaction effects (ORs and 95% CIs) of race, age, stage and cohort were estimated from logistic regression models. All effects were age-adjusted in logistic regression models that treated non-linear age (lower survival among the youngest and oldest) as a categorical variable: 25–44 (reference category), 45–54, 55–64, 65–74, 75 years of age and older

^aRacial groups: African American and non-Hispanic white. Age groups: less than 65 years of age (not yet Medicare eligible) and 65 years of age and older (Medicare eligible). Stage of disease at diagnosis groups: node negative (localized and regional), regional node positive, and distant or metastasized disease. Cohorts: diagnosed in the 1970s and 1990s

^bSignificant 2-way interaction, P<0.05

^cSignificant 3-way interaction, P<0.05

^dSignificant 4-way interaction, P<0.05