Table 2.

Effects of race moderated by age and cohort within breast cancer stage of disease at diagnosis^a on receipt of cancer-directed treatments: incidence cohorts diagnosed between 1975 and 1984, and 1990 and 1999 were followed until January 1, 1986 and 2001

Age							Adjusted for socioeconomic statusb
	1970s and 1980s cohort			1990s cohort			1970s and 1980s cohort			1990s cohort
	n	OR	95% CI	n	OR	95% CI	n	OR	95% CI	n	OR	95% CI
Node negative breast cancer
	Race moderated by age and cohort on surgeryc						Race moderated by age and cohort on surgeryc
<65	6,991	2.04	1.23, 3.38	8,854	1.65	1.02, 2.68	4,724	1.01	0.49, 2.11	8,803	1.66	0.87, 3.20
65+	4,198	2.74	1.66, 4.51	8,879	1.50	0.89, 2.52	3,074	2.40	1.26, 4.60	8,828	1.22	0.65, 2.29
Node positive breast cancer
	Race moderated by age and cohort on radiation therapyc						Race moderated by age and cohort on radiation therapy
<65	3,069	0.84	0.68, 1.04	4,642	1.12	0.98, 1.28d	2,459	0.87	0.68, 1.11	4,615	0.93	0.79, 1.11
65+	1,461	1.04	0.74, 1.46	2,759	1.08	0.88, 1.33	1,123	1.06	0.71, 1.58	2,743	0.93	0.72, 1.21
	Race moderated by age and cohort on chemotherapyc						Race moderated by age and cohort on chemotherapy
<65	3,082	1.05	0.87, 1.27	4,644	1.19	1.04, 1.36	2,476	0.90	0.72, 1.12	4,617	0.97	0.81, 1.15
65+	1,464	1.53	1.11, 2.11	2,759	0.90	0.73, 1.12	1,124	1.36	0.94, 1.97	2,743	0.94	0.71, 1.23
	Race moderated by age and cohort on hormone therapyc						Race moderated by age and cohort on hormone therapy
<65	3,083	0.90	0.71, 1.14	4,643	1.15	0.97, 1.35d	2,476	0.86	0.62, 1.19	4,616	1.01	0.82, 1.25
65+	1,464	0.98	0.68, 1.41	2,757	1.05	0.85, 1.29	1,124	0.91	0.60, 1.38	2,741	0.90	0.69, 1.17

Notes: n = number of incident female breast cancer cases, OR = odds ratio, CI = confidence interval. Main and interaction effects of race, age, stage and cohort were estimated from logistic regression models (ORs and 95% CIs estimated from regression statistics). All effects were age-adjusted in logistic regression models that treated non-linear age (lower survival among the youngest and oldest) as a categorical variable: 25–44 (reference category), 45–54, 55–64, 65–74, 75 years of age and older

^aRacial groups: African American and non-Hispanic white. Age groups: less than 65 years of age (not yet Medicare eligible) and 65 years of age and older (Medicare eligible). Cohorts: 1970–1980s and 1990s. Stage of disease at diagnosis groups: node negative (localized and regional) and regional node positive. Distant breast cancers that had already metastasized at the time of diagnosis were excluded

^bAdjusted for poverty: low, middle and high poverty areas based on census tract prevalence below the federal poverty criterion [49–52]

^cStatistically significant 3-way interaction, P<0.05

^d90% confidence interval does not include the null (P<0.10)