Figure 9.
d-Alanine-induced d-serine release from slices. A) endogenous d-serine release from acute cortical slices promoted by perfusion with 0.5 mM d-alanine. B) d-[3H]serine release from acute cortical slices promoted by perfusion with 0.5 mM d-alanine. C) Effect of d-alanine perfusion on veratridine-elicited d-[3H]serine release. Slices preloaded with d-[3H]serine were first perfused with solution containing either none (○) or 0.5 mM d-alanine (•). After d-alanine washout, further d-[3H]serine release was induced by perfusion with 50 μM veratridine. D) Quantitative analysis of effect of veratridine in slices with and without previous perfusion with d-alanine as in C. ** P < 0.01 vs. control.