TABLE 2.
CI values for chemotherapeutic agents plus pyrimidine-derivatives in D283-MED cell line
| Agent | S7 |
||
|---|---|---|---|
| 3.75 μM | 7.5 μM | 25 μM | |
| Etoposide | |||
| 15 μM | 0.286 ± 0.003 | 0.315 ± 0.007 | 0.514 ± 0.007 |
| 25 μM | 0.162 ± 0.001 | 0.231 ± 0.005 | 0.408 ± 0.01 |
| 50 μM | 0.118 ± 0.007 | 0.096 ± 0.01 | 0.225 ± 0.07 |
| Cisplatin | |||
| 7.5 μM | 0.504 ± 0.002 | 0.669 ± 0.01 | 1.293 ± 0.002 |
| 15 μM | 0.690 ± 0.0008 | 0.429 ± 0.007 | 0.744 ± 0.009 |
| 25 μM | 0.692 ± 0 | 0.633 ± 0.007 | 0.758 ± 0.007 |
Values are means ± sd of ≥3 independent experiments done in quadruplicate. CI values were calculated according to Chou-Talalay by isobologram analysis done on CalcuSyn software.