Figure 6.

Projection to latent structure discriminant analysis (PLS-DA) of metabolomic profiles while fed the baseline choline-adequate diet separates participants who will develop fatty liver from participants who will not develop organ dysfunction when fed a choline-deficient diet. Samples were obtained at the end of the baseline choline-adequate diet period and analyzed as described in Fig. 1. Using baseline data, PLS-DA provides a good separation of the group that will develop fatty liver (solid squares) from those who will not develop organ dysfunction (open squares) when fed a choline-deficient diet. Metabolites used for this separation are shown in Table 1.