Figure 6.

Heat maps of REMc clusters illustrate hierarchical relationships and cluster quality. Heat maps represent each round of REMc. Each REM cluster was subjected to Hc to produce a gene dendrogram and heat map. Green shading indicates synergistic interaction, and blue shading indicates antagonistic interaction (see scale). The interaction values (each shaded box) correspond to Growth Index scores (described in Sec. 1 and reproduced in supplementary material) (Ref. ⁵). The cluster names are given to left of heat map. GOid_z and LL are displayed to the right of clusters (rank indicated in parentheses). Gene names are given along the right side of each heat map. Drug treatment conditions are labeled A-N at the bottom and the same order is maintained for each cluster, as detailed for cluster 0. See text and supplemental material for additional detail about each perturbation (Ref. ²⁴).