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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Dev Biol. 2010 May 4;344(1):185–195. doi: 10.1016/j.ydbio.2010.04.031

Figure 3. Loss of anterior neural progenitors in early nehe embryos.

Figure 3

Otx2 is expressed throughout the headfolds of wild-type e8.5 embryos (A) but is detected only at the midline of stage-matched mutant embryos (B) (n=4). The embryos in (A) and (B) are both at the four somite stage. At the headfold stage (e7.75), Otx2 is expressed in the neurectoderm to the anterior end of the embryo, all the way to the embryonic/extraembryonic boundary (C), but Otx2 is more weakly expressed in stage-matched nehe embryos and does not extend as far anteriorly (red arrow) (D) (n=2). The embryos in (C) and (D) are stage matched based on the length of the allantois (black arrows). Hesx1 is expressed in the anterior neurectoderm of wild-type embryos (E), but is not expressed in the most anterior neurectoderm of nehe mutants (red arrow) (F) (n=4). Scale bars: 0.25mm.