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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Mar 6;1802(12):1219–1229. doi: 10.1016/j.bbadis.2010.02.011

Fig. 2.

Fig. 2

Oubain, but not digoxin, induces hypertension; digoxin and digitoxin reverse ouabain-induced hypertension. Rats were infused with vehicle (■), ouabain, 15 μg/kg/day (▼), or digoxin, 30 μg/kg/day (▲), for 42 days. From days 35 to 42, three groups of 8 ouabain-infused rats received a secondary infusion of digoxin, 30 μg/kg/day (●), digitoxin, 30 μg/kg/day (○), or vehicle (▼). Mean blood pressures (MBP) were obtained by tail cuff at weekly intervals or as indicated. *P<0.05 vs ouabain; ***P<0.001 vs ouabain; #P<0.005 vs vehicle; **P<0.001 vs digoxin. Reprinted with permission [99].

Effects of Ouabain, Digoxin and Digitoxin on BP