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. 2010 Jan;40(1):117–123. doi: 10.1002/eji.200939863

Figure 3.

Figure 3

L. donovani induces expression of SIRPα on KC. (A) Livers from naive B6 mice or mice infected with L. donovani 1, 2.5 or 5 h previously were stained for SIRPα (green) and L. donovani AM (red). Images are representative of four independent experiments. (B) Hepatic SIRPα mRNA accumulation, shown as fold increase relative to naïve mice at timepoints indicated. (C) SIRPα expression on KC in control and PTx-treated mice infected with L. donovani. Data in (B) and (C) are representative of two independent experiments. (D) Proposed model for regulation of APC–iNKT-cell interactions through CD47-SIRPα signalling. On splenic APC, constitutively expressed SIRPα engages CD47 and enhances the TCR-dependent IFN-γ response of iNKT cells. In the liver, SIRPα is not constitutively expressed on KC, but expression can be induced in response to chemokines produced as a result of L. donovani infection.