Table 1.
Nucleic acid sensors.
| Sensor | Ligand | Reference |
|---|---|---|
| TLR-9 | Hypomethylated CpG-DNA | [18] |
| DAI/ZBP1 | dsDNA | [82] |
| RNA-Pol III | dsDNA (AT-rich) | [101,102] |
| HIN-200 (p202) | dsDNA | [72] |
| AIM-2 | dsDNA | [73] |
| TLR-3 | dsRNA, poly I : C | [22] |
| TLR-7 | ssRNA, imiquimod, Loxoribine, R848 | [20] |
| TLR-8 | ssRNA, R848 | [20] |
| RIG-I | dsRNA, 3P-ssRNA, short poly I : C | [104] |
| MDA-5 | dsRNA, long poly I : C | [105] |
| LGP2 | dsRNA, 3P-ssRNA | [104] |
AIM-2, absent in melanoma 2; DAI, DNA-dependent activator of IRFs/Z-DNA binding protein 1; HIN, haematopoietic IFN-inducible nuclear protein; LGP2, RIG-I-like RNA-helicase; MDA, melanoma differentiation-associated gene 5; RIG, retinoic acid-inducible gene-I; TLR, Toll-like receptor.