Histological results (a) and representative appearance of joints from rats treated with phosphate-buffered saline (PBS), immunoglobulin G (IgG), D8, G7 and G8 antibodies. (a) Results of histological scoring in rats treated with PBS, IgG, D8, G7 and G8, respectively. An intense inflammatory infiltrate is obvious in the synovial tissue in rats treated with PBS (b) and is absent in rats treated with D8200 µg (c) (haematoxylin and eosin staining).