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Post-mortem X-ray analysis of joints from rats treated with phosphate-buffered saline (PBS) (a) and D8 (b). (a) Intense periarticular soft tissue swelling is evident in the PBS-treated rats (star), as well as decalcification and early bony erosion at the ankle joint (arrow head); these findings are not evident in the D8-treated rats (b) (representative figures). Similar results were seen in X-rays of the forefeet (not shown).
