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Effect of compounds 27519 and 27549 on exogenous proteinase 3 (PR3) binding to neutrophils; (a) 1 × 106 neutrophils were treated for 30 min with buffer, 50 µM compound 27519, compound 27549 or the control compound 39679 (control), respectively. Cells were then incubated with 1 µg PR3 for 90 min. Membrane PR3 expression was assessed by flow cytometry using the CLB anti-PR3 monoclonal antibody (n = 5). (b) A typical flow experiment is depicted for compound 27519. **P < 0·01.
